Genes involved in senescence and immortalization.
Curr Opin Cell Biol
; 12(6): 705-9, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11063935
ABSTRACT
Senescence is now understood to be the final phenotypic state adopted by a cell in response to several distinct cell physiological processes, including proliferation, oncogene activation and oxygen free radical toxicity. The role of telomere maintenance in immortalization and the roles of p16(INK4A), p19(ARF), p53 and other genes in senescence are being further elucidated. Significant progress continues to be made in our understanding of cellular senescence and immortalization.
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Colección:
01-internacional
Asunto principal:
Senescencia Celular
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos