Immunological enhancement of primary tumor development and its prevention.
Semin Cancer Biol
; 10(5): 351-7, 2000 Oct.
Article
en En
| MEDLINE
| ID: mdl-11100883
ABSTRACT
While it has been known for decades that the growth of tumor transplants can be enhanced immunologically, the potential significance of these previous findings to the development of primary tumors and the mechanisms of tumor enhancement has remained obscure. This review will summarize recent experiments indicating that primary tumor development can be enhanced by active immunization. The evidence suggests that antibodies, B cells and CD4+ T cells can play a critical role in enhancing the development of primary, tumors, whereas endogenous interferon-gamma (IFNgamma) can counteract enhancement. Thus, we envision two possible functions of IFNgamma (i) preventing B cell and antibody enhancement and (ii) counteracting tumor promotion independent of T and B cells.
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Colección:
01-internacional
Asunto principal:
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Semin Cancer Biol
Asunto de la revista:
NEOPLASIAS
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos