Thiazolidinedione- and tumor necrosis factor alpha-induced downregulation of peroxisome proliferator-activated receptor gamma mRNA in differentiated 3T3-L1 adipocytes.
Metabolism
; 50(1): 36-40, 2001 Jan.
Article
en En
| MEDLINE
| ID: mdl-11172472
ABSTRACT
Thiazolidinediones (TZDs) are antidiabetic insulin-sensitizing agents that bind to peroxisome proliferator-activated receptor gamma (PPARgamma) and have potent adipogenic effects on 3T3-L1 preadipocytes. In fully differentiated 3T3-L1 adipocytes, TZDs markedly decreased PPARgamma mRNA levels without reducing the expression of genes that are positively regulated by PPARgamma, such as adipocyte lipid-binding protein 2 (aP2) or lipoprotein lipase-(LPL). PPARgamma mRNA levels were also downregulated by tumor necrosis factor alpha (TNFalpha), an antiadipogenic cytokine. We propose that the downregulation of PPARgamma is not the common denominator of the metabolic effects of TZDs and TNFalpha on mature adipocytes.
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Colección:
01-internacional
Asunto principal:
Tiazoles
/
Factores de Transcripción
/
Expresión Génica
/
Factor de Necrosis Tumoral alfa
/
Receptores Citoplasmáticos y Nucleares
/
Adipocitos
/
Tiazolidinedionas
Límite:
Animals
Idioma:
En
Revista:
Metabolism
Año:
2001
Tipo del documento:
Article
País de afiliación:
Japón