Guinea pig histamine N-methyltransferase: cDNA cloning and mRNA distribution.
Jpn J Pharmacol
; 85(1): 105-8, 2001 Jan.
Article
en En
| MEDLINE
| ID: mdl-11243563
ABSTRACT
We report here the isolation of histamine N-methyltransferase (HMT) cDNA from the guinea pig brain by the polymerase chain reaction on the basis of nucleotide sequences of rat and human counterparts. Guinea pig HMT consists of 292 amino acids, with homologies of 75.6% and 79.1% to rat and human HMT, respectively. Northern blotting analysis indicated that the 1.6-kb guinea pig HMT transcript was expressed at various levels in different tissues at the following relative abundance jejunum, brain > lung, spleen, stomach > liver, kidney. HMT mRNA localized throughout the jejunum, and it was mainly expressed in epithelial cells and in Auerbach's plexus.
Buscar en Google
Colección:
01-internacional
Asunto principal:
ARN Mensajero
/
ADN Complementario
/
Histamina N-Metiltransferasa
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Jpn J Pharmacol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Japón