BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
Cell
; 105(1): 149-60, 2001 Apr 06.
Article
en En
| MEDLINE
| ID: mdl-11301010
ABSTRACT
BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase family. BACH1 binds directly to the BRCT repeats of BRCA1. A BACH1 derivative, bearing a mutation in a residue that was essential for catalytic function in other helicases, interfered with normal double-strand break repair in a manner that was dependent on its BRCA1 binding function. Thus, BACH1/BRCA1 complex formation contributes to a key BRCA1 activity. In addition, germline BACH1 mutations affecting the helicase domain were detected in two early-onset breast cancer patients and not in 200 matched controls. Thus, it is conceivable that, like BRCA1, BACH1 is a target of germline cancer-inducing mutations.
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Colección:
01-internacional
Asunto principal:
Neoplasias de la Mama
/
ADN Helicasas
/
Proteína BRCA1
/
ARN Helicasas
/
Proteínas de Unión al ADN
/
Reparación del ADN
Límite:
Adult
/
Female
/
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Cell
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos