Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice.
J Immunol
; 167(5): 2671-6, 2001 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-11509610
ABSTRACT
Interaction of 4-1BB (CD137) and its ligand (4-1BBL) is thought to positively regulate cell-mediated and humoral immune responses. We have prepared transgenic mouse strains that express 4-1BBL cDNA under the control of MHC class II I-Ealpha promoter. The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of B220(+) B cells accompanied with low levels of circulating IgG and defective humoral responses to Ag challenge. In addition, splenocytes from the transgenic mice fail to provide stimulation for allogeneic T cells in both lymphoproliferative and CTL responses in vitro, whereas their T cells remain functionally normal. Our results reveal unexpected functions of 4-1BBL in the regulation of humoral immune responses and Ag presentation.
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Colección:
01-internacional
Asunto principal:
Linfocitos B
/
Antígenos de Histocompatibilidad Clase II
/
Factor de Necrosis Tumoral alfa
/
Receptores de Factor de Crecimiento Nervioso
/
Receptores del Factor de Necrosis Tumoral
Límite:
Animals
Idioma:
En
Revista:
J Immunol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos