Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium.
J Exp Med
; 194(8): 1033-42, 2001 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-11602634
ABSTRACT
Continuous lymphocyte recirculation between blood and lymphoid tissues forms a basis for the function of the immune system. Lymphocyte entrance from the blood into the tissues has been thoroughly characterized, but mechanisms controlling lymphocyte exit from the lymphoid tissues via efferent lymphatics have remained virtually unknown. In this work we have identified mannose receptor (MR) on human lymphatic endothelium and demonstrate its involvement in binding of lymphocytes to lymphatic vessels. We also show that the binding requires L-selectin, and L-selectin and MR form a receptor-ligand pair. On the other hand, L-selectin binds to peripheral lymph node addressins (PNAds) on high endothelial venules (HEVs) that are sites where lymphocytes enter the lymphatic organs. Interestingly, MR is absent from HEVs and PNAds from lymphatic endothelium. Thus, lymphocyte L-selectin uses distinct ligand molecules to mediate binding at sites of lymphocyte entrance and exit within lymph nodes. Taken together, interaction between L-selectin and MR is the first molecularly defined mechanism mediating lymphocyte binding to lymphatic endothelium.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Endotelio Linfático
/
Linfocitos
/
Receptores de Superficie Celular
/
Selectina L
/
Lectinas Tipo C
/
Lectinas de Unión a Manosa
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Exp Med
Año:
2001
Tipo del documento:
Article
País de afiliación:
Finlandia