What can transgenic and gene-targeted mouse models teach us about salivary gland physiology?
Adv Dent Res
; 14: 5-11, 2000 Dec.
Article
en En
| MEDLINE
| ID: mdl-11842924
ABSTRACT
Thousands of genetically modified mice have been developed since the first reports of stable expression of recombinant DNA in this species nearly 20 years ago. This mammalian model system has revolutionized the study of whole-animal, organ, and cell physiology. Transgenic and gene-targeted mice have been widely used to characterize salivary-gland-specific expression and to identify genes associated with tumorigenesis. Moreover, several of these mouse lines have proved to be useful models of salivary gland disease related to impaired immunology, i.e., Sjögren's syndrome, and disease states associated with pathogens. Despite the availability of genetically modified mice, few investigators have taken advantage of this resource to better their understanding of salivary gland function as it relates to the production of saliva. In this article, we describe the methods used to generate transgenic and gene-targeted mice and provide an overview of the advantages of and potential difficulties with these models. Finally, using these mouse models, we discuss the advances made in our understanding of the salivary gland secretion process.
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Colección:
01-internacional
Asunto principal:
Enfermedades de las Glándulas Salivales
/
Glándulas Salivales
/
Ratones Transgénicos
/
Marcación de Gen
Límite:
Animals
Idioma:
En
Revista:
Adv Dent Res
Asunto de la revista:
ODONTOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos