Structure of dengue virus: implications for flavivirus organization, maturation, and fusion.
Cell
; 108(5): 717-25, 2002 Mar 08.
Article
en En
| MEDLINE
| ID: mdl-11893341
ABSTRACT
The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Virus del Dengue
Límite:
Humans
Idioma:
En
Revista:
Cell
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos