[Embryotoxic and teratogenic action of some pesticides]. / Embriotoksichno i teratogenno deistvie na niakoi pestitsidi

ABSTRACT

The authors carried out experiments on white rats in order to evaluate embriotoxic and teratogenic effect of pesticides cyneb, mneb, cypromate, basfungine, remrod, dipterex and bromex. The preparations were administered oraly as followed 1) singly in the course of whole pregnancy in a dose of 1/2 LD50 and lower doses till finding single nonacting dose and 21 in the course of the whole pregnancy in doses rangling from the determined single threshold dose till finding minimal acting dose during multiple application and nonacting teratogenic dose under the same conditions. The authors examined the changes in some liver enzymic systems of the mother and fetus. It was established that there was raised actitity of LDH, A1Ph, AcPh, glucose -6-phosphat-dehydrogenase and HEA with degree differences in both examined categories - the mother and fetus. Single treatment of pregnant rats during the period of organogenesis induced anomalies in the development of the nervous system; of the skeletal system - facial cranium, extremities, tail as well as functional and biochemical changes. The authors determined teratogenically nonacting doses for single application for cyneb - 1000 mg/kg; for maneb - 50 mg/kg and for cypronat - 250 mg/kg.