Cyclic recovery of adenovirus in a stem cell transplant recipient: an inverse association with graft-versus-host disease.
Bone Marrow Transplant
; 31(4): 301-3, 2003 Feb.
Article
en En
| MEDLINE
| ID: mdl-12621467
ABSTRACT
Adenovirus (AdV) infections have been increasingly recognized as significant pathogens that may cause severe morbidity and mortality among stem cell transplant (SCT) recipients. AdV can cause localized infections such as hemorrhagic cystitis (HC), pneumonia, hepatitis and also disseminated disease that can lead to death. We report a case of severe hemorrhagic cystitis in a SCT recipient who died 83 days after transplant. In this patient, AdV recovery was not constantly detected. In fact, fluctuations of the AdV detection in leukocytes and urine were observed by culture and PCR. When analyzing this viral cyclic recovery with different signs or symptoms in the patient, we observed an inverse association with the presence of acute graft-versus-host disease (GVHD). Whether these fluctuations represent donor-derived reactivity, indirectly manifested by the presence of GVHD, requires further study. This is the first case describing a dynamic pattern of AdV replication in leukocytes and urine samples from a patient with severe HC and the temporal correlation with GVHD.
Buscar en Google
Colección:
01-internacional
Asunto principal:
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Adenovirus Humanos
/
Trasplante de Células Madre
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Bone Marrow Transplant
Asunto de la revista:
TRANSPLANTE
Año:
2003
Tipo del documento:
Article
País de afiliación:
Argentina