Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20.
Blood
; 102(9): 3206-9, 2003 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-12855566
ABSTRACT
In a search for novel growth factors, we discovered that human interleukin-20 (IL-20) enhanced colony formation by CD34+ multipotential progenitors. IL-20 had no effect on erythroid, granulocyte-macrophage, or megakaryocyte progenitors. IL-20 transgenic mice increased the numbers and cell cycling of multipotential but not other progenitors. IL-20 administration to normal mice significantly increased only multipotential progenitor cells, demonstrating that IL-20 significantly influences hematopoiesis, with specificity toward multipotential progenitors. This is the first cytokine with such specificity identified.
Buscar en Google
Colección:
01-internacional
Asunto principal:
Células Madre Hematopoyéticas
/
Interleucinas
/
Células Madre Multipotentes
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Blood
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos