Differential effects of intravenous hydralazine on myoendometrial and placental blood flow in hypertensive pregnant ewes.
Am J Obstet Gynecol
; 167(6): 1672-8, 1992 Dec.
Article
en En
| MEDLINE
| ID: mdl-1471685
ABSTRACT
OBJECTIVE:
The differential vasoactive effects of hydralazine on the uteroplacental vascular bed were studied. STUDYDESIGN:
After control measurements were taken, near-term chronically prepared pregnant sheep were continuously infused with angiotensin II. Maternal arterial pressure was increased by 32 mm Hg. Hydralazine was then administered; the effects on regional resistance and blood flow were evaluated with a radionuclide-labeled microsphere technique. Analysis of variance for repeated measures was used to compare observations.RESULTS:
When compared with the hypertensive state, hydralazine caused the following changes by 40 minutes (mean +/- SEM) Although maternal blood pressure fell 31% +/- 5% (p = 0.0005), placental blood flow was unchanged, total uteroplacental blood flow increased 24% +/- 8% (p = 0.03), total uteroplacental resistance decreased 43% +/- 4% (p = 0.0002), placental resistance decreased 19% +/- 9% (p = 0.01), myoendometrial blood flow increased 390% +/- 82% (p = 0.0005), and myoendometrial resistance decreased 82% +/- 4% (p = 0.0005).CONCLUSIONS:
In angiotensin II-induced hypertensive ewes, hydralazine is an effective dilator of the uteroplacental vascular bed and can maintain placental blood flow while blood pressure.
Buscar en Google
Colección:
01-internacional
Asunto principal:
Endometrio
/
Hidralazina
/
Hipertensión
/
Miometrio
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Año:
1992
Tipo del documento:
Article