Oxidative study of patients with total body irradiation: effects of amifostine treatment.
Bone Marrow Transplant
; 33(8): 793-8, 2004 Apr.
Article
en En
| MEDLINE
| ID: mdl-14990982
ABSTRACT
In patients undergoing bone marrow transplant (BMT), reactive oxygen species (ROS) are released as a consequence of the events related to the preparative regimen. Total body irradiation (TBI), which is known to generate ROS, is a routine preconditioning procedure prior to BMT. Several studies have demonstrated that amifostine protects normal tissues. In the present report, we investigated the oxidative state of plasma and erythrocytes in 21 patients with hematological malignancies undergoing TBI. The dose fraction was 160 cGy, twice daily (eight sessions). For ROS detection, we used electron spin resonance spectroscopy and spin-trapping technique. In all, 15 patients received amifostine prior to the irradiation and six did not. No free radical signal was detected in the plasma samples spectrum of 15 amifostine-treated patients, and five of six samples of nontreated patients showed ROS signal. Only two of 15 treated patients had mucositis degree higher than 2, whereas five of six nontreated patients suffered this complication. The average hospitalization days in treated and nontreated patients were 23.5 and 29.7, respectively. This work represents an original observation; we found by direct measurements of free radicals that ROS are released during TBI, and confirmed the amifostine radical scavenger activity.
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Colección:
01-internacional
Asunto principal:
Protectores contra Radiación
/
Irradiación Corporal Total
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Especies Reactivas de Oxígeno
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Amifostina
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Acondicionamiento Pretrasplante
Límite:
Adolescent
/
Adult
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Bone Marrow Transplant
Asunto de la revista:
TRANSPLANTE
Año:
2004
Tipo del documento:
Article
País de afiliación:
Argentina