Deficiency of Bax and Bak protects photoreceptors from light damage in vivo.
Cell Death Differ
; 11(11): 1192-7, 2004 Nov.
Article
en En
| MEDLINE
| ID: mdl-15272317
ABSTRACT
Photoreceptors of bax(-/-)bak(-/-) but neither bax(-/-) mice nor bak(-/-) mice are protected from developmental apoptosis, suggesting that bax(-/-)bak(-/-) photoreceptors may also be protected from pathologic apoptosis. To test this possibility, we exposed bax(-/-)bak(-/-) and bax(-/-) mice to bright light, which normally induces photoreceptor death. Photoreceptors in bax(-/-)bak(-/-) mice were protected from death compared to bax(-/-) mice as indicated by a reduction in the number of TUNEL-positive photoreceptor nuclei 24 h following light damage and almost complete preservation of photoreceptors 7 days following light damage. These results provide the first in vivo evidence that combined deficiency of Bax and Bak can rescue cells from a pathologic stimulus more effectively than Bax deficiency and suggest that combined deficiency of Bax and Bak may also protect cells from other insults.
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Colección:
01-internacional
Asunto principal:
Lesiones Oculares
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Ojo
/
Proteínas de la Membrana
Límite:
Animals
Idioma:
En
Revista:
Cell Death Differ
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos