Interferon alfa treatment for pregnant women affected by essential thrombocythemia: case reports and a review.
Am J Obstet Gynecol
; 191(6): 2016-20, 2004 Dec.
Article
en En
| MEDLINE
| ID: mdl-15592285
ABSTRACT
OBJECTIVES:
In the past essential thrombocythemia was considered a disease of the elderly. At present, the number of young people suffering from this disease is growing, with a slightly higher frequency in females. We investigated the effects of interferon alfa therapy in these patients. STUDYDESIGN:
We describe 9 pregnancies in 4 women affected by essential thrombocythemia.RESULTS:
Four pregnancies were carried out without interferon alfa therapy, and resulted in 2 intrauterine deaths, 1 spontaneous abortion, and 1 neonatal death. Interferon alfa was given during another 5 pregnancies; among them, 2 ended in preterm deliveries with normal infants, and 3 in full-term deliveries. The literature is reviewed.CONCLUSION:
Our cases and published series suggest that fetal outcome is improved by therapy, and that interferon alfa may be the best therapeutic option.
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Colección:
01-internacional
Asunto principal:
Complicaciones Hematológicas del Embarazo
/
Resultado del Embarazo
/
Interferón-alfa
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Trombocitemia Esencial
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Año:
2004
Tipo del documento:
Article
País de afiliación:
Italia