Estrogen receptor-related receptor alpha: a mediator of estrogen response in bone.
J Clin Endocrinol Metab
; 90(5): 3115-21, 2005 May.
Article
en En
| MEDLINE
| ID: mdl-15713703
ABSTRACT
Estrogen receptor-related receptor-alpha (ERRalpha) is an orphan nuclear receptor with sequence homology to the estrogen receptors, ERalpha/beta, but it does not bind estrogen. However, several recent studies suggest that ERRalpha not only plays a functional role in osteoblasts but also impinges on the estrogen axis in bone, as it does in at least certain other estrogen target tissues. We summarize here data on ERRalpha and its cellular and molecular modes of action that have broad implications for considering the potential role of this orphan receptor as a new therapeutic target in osteopenic disorders such as osteoporosis as well as other estrogen-responsive conditions.
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Colección:
01-internacional
Asunto principal:
Huesos
/
Receptores de Estrógenos
/
Receptores Citoplasmáticos y Nucleares
/
Estrógenos
Límite:
Humans
Idioma:
En
Revista:
J Clin Endocrinol Metab
Año:
2005
Tipo del documento:
Article
País de afiliación:
Canadá