Telomere and telomerase dynamics in human cells.
Curr Mol Med
; 5(2): 227-31, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15974877
ABSTRACT
Accumulating evidence now implicates telomeres and telomerase as critical regulators genomic stability and replicative lifespan in mammalian cells. Disruption of telomere maintenance and/or telomerase expression contributes to the etiology of some degenerative diseases and may participate in the process of aging. Although telomere dysfunction and aberrant telomerase expression clearly play important roles in cancer development, the contribution of telomere biology to cancer is complex and involves both positive and negative influences on tumor development. Indeed, recent work from several laboratories suggests additional roles for telomeres and telomerase in both normal and malignant physiology. Understanding the complexity of telomere biology will provide further insights into chromosome biology in both normal and malignant cells.
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Colección:
01-internacional
Asunto principal:
Telómero
/
Senescencia Celular
/
Telomerasa
/
Inestabilidad Genómica
Límite:
Humans
Idioma:
En
Revista:
Curr Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos