Costello syndrome and hyperinsulinemic hypoglycemia.
Am J Med Genet A
; 139(3): 227-30, 2005 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-16278907
ABSTRACT
Costello syndrome is characterized by mental retardation, loose skin, coarse facies, skeletal abnormalities, cardiovascular abnormalities (congenital heart defects, cardiomyopathy, rhythm disturbances), and predisposition to neoplasia. Endocrine abnormalities including growth hormone deficiency, adrenal insufficiency, glucose intolerance, parathyroid adenoma with hyperprolactinemia and hypoglycemia have been described. Hypoglycemia has been documented due to growth hormone and cortisol deficiency. We report on two patients with Costello syndrome and persistent hyperinsulinemic hypoglycemia and review the endocrine manifestations of Costello syndrome. Both patients required diazoxide therapy to stop the unregulated insulin secretion and maintain normoglycemia. The mechanism of persistent hyperinsulinism in patients with Costello syndrome is unclear.
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Colección:
01-internacional
Asunto principal:
Anomalías Múltiples
/
Hiperinsulinismo
/
Hipoglucemia
/
Discapacidad Intelectual
Límite:
Female
/
Humans
/
Newborn
Idioma:
En
Revista:
Am J Med Genet A
Asunto de la revista:
GENETICA MEDICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Reino Unido