Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses.
J Infect Dis
; 193(12): 1619-25, 2006 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-16703503
ABSTRACT
We conducted a 12-year retrospective study to determine the effects that the community respiratory-virus species and the localization of respiratory-tract virus infection have on severe airflow decline, a serious and fatal complication occurring after hematopoietic cell transplantation (HCT). Of 132 HCT recipients with respiratory-tract virus infection during the initial 100 days after HCT, 50 (38%) developed airflow decline < or =1 year after HCT. Lower-respiratory-tract infection with parainfluenza (odds ratio [OR], 17.9 [95% confidence interval {CI}, 2.0-160]; P=.01) and respiratory syncytial virus (OR, 3.6 [95% CI, 1.0-13]; P=.05) independently increased the risk of development of airflow decline < or =1 year after HCT. The airflow decline was immediately detectable after infection and was strongest for lower-respiratory-tract infection with parainfluenza virus; it stabilized during the months after the respiratory-tract virus infection, but, at < or =1 year after HCT, the initial lung function was not restored. Thus, community respiratory virus-associated airflow decline seems to be specific to viral species and infection localization.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Infecciones del Sistema Respiratorio
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Infecciones Comunitarias Adquiridas
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Trasplante de Células Madre Hematopoyéticas
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Ventilación Pulmonar
Tipo de estudio:
Etiology_studies
/
Observational_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Infect Dis
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos