Morphologic and immunohistochemical characterization of Leydig cell tumor variants in Wistar rats.
Toxicol Pathol
; 19(3): 280-6, 1991.
Article
en En
| MEDLINE
| ID: mdl-1723533
ABSTRACT
During a routine long-term drug safety study, lasting approximately 2 1/2 yr, male Wistar rats, treated with a prolactin-inhibiting compound, developed an excess of Leydig cell tumors (LCTs). Most tumors were typical for the rat but a small number showed an unusual variation and some appeared malignant. The variation consisted of glandular and/or tubular structures within the tumor mass which occasionally anastomosed and contained an eosinophilic periodic-acid Schiff (PAS) positive material. In a few of these variants, malignant features such as cellular atypia, capsular, and lymphatic invasion and necrosis were seen. No metastases were detected. Detailed morphological and immunohistochemical investigations were conducted in order to establish the cell of origin of these variants. Glandular/tubular structures were found to stain with varying intensity for vimentin and cytokeratin, but were always negative for beta-tubulin. The results indicated that the cell of origin of these LCT variants was indeed the Leydig cell and that glandular and/or tubular structures within LCTs represented a form of Leydig cell metaplasia.
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Colección:
01-internacional
Asunto principal:
Neoplasias Testiculares
/
Tumor de Células de Leydig
Límite:
Animals
Idioma:
En
Revista:
Toxicol Pathol
Año:
1991
Tipo del documento:
Article
País de afiliación:
Suiza