Prevalence and distribution of HPV genotypes among HIV-infected women in Zambia.
Br J Cancer
; 96(9): 1480-3, 2007 May 07.
Article
en En
| MEDLINE
| ID: mdl-17437020
ABSTRACT
We screened 145 HIV-infected non-pregnant women at a tertiary care centre in Lusaka, Zambia. Liquid-based cytology and human papillomavirus (HPV) genotyping with PGMY09/11 biotinylated primers (Roche Linear Array HPV genotyping test) maximised sensitivity of cytology and HPV assessments. Among high-risk (HR) types, HPV 52 (37.2%), 58 (24.1%) and 53 (20.7%) were more common overall than HPV 16 (17.2%) and 18 (13.1%) in women with high-grade squamous intraepithelial lesions or squamous cell carcinoma (SCC) on cytology. High-risk HPV types were more likely to be present in women with CD4+ cell counts <200 microl(-1) (odds ratios (OR) 4.9, 95% confidence intervals (CI) 1.4-16.7, P=0.01) and in women with high-grade or severe cervical cytological abnormalities (OR 8.0, 95% CI 1.7-37.4, P=0.008). Human papillomavirus diversity in high-grade lesions and SCC on cytology suggests that HPV 16- and 18-based vaccines may not be adequately polyvalent to induce protective immunity in this population.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Papillomaviridae
/
Infecciones por VIH
/
Infecciones por Papillomavirus
Tipo de estudio:
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
Br J Cancer
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos