Angiogenesis and mast cells in human breast cancer sentinel lymph nodes with and without micrometastases.
Histopathology
; 51(6): 837-42, 2007 Dec.
Article
en En
| MEDLINE
| ID: mdl-17944928
ABSTRACT
AIMS:
An increasing number of mast cells have been reported in angiogenesis associated with solid and haematopoietic tumours. Data concerning the number of mast cells in neoplastic lymph nodes and their relationship with microvessel density are controversial. The aim was to correlate the extent of angiogenesis with the number of mast cells reactive with tryptase in biopsy specimens of sentinel lymph nodes with and without micrometastases obtained from patients with breast cancer. METHODS ANDRESULTS:
Specimens from sentinel lymph nodes obtained from 80 patients (40 with and 40 without micrometastases) were investigated immunohistochemically by using anti-CD31 and anti-tryptase antibodies. Angiogenesis, measured as microvessel counts, increased in parallel with the number of tryptase-positive mast cells and their values were significantly higher in lymph nodes with micrometastases compared with those without.CONCLUSIONS:
Tryptase-positive mast cells may contribute, at least in part, to angiogenesis occurring in sentinel lymph nodes with micrometastases from patients with breast cancer.
Buscar en Google
Colección:
01-internacional
Asunto principal:
Neoplasias de la Mama
/
Ganglios Linfáticos
/
Metástasis Linfática
/
Mastocitos
/
Neovascularización Patológica
Límite:
Female
/
Humans
Idioma:
En
Revista:
Histopathology
Año:
2007
Tipo del documento:
Article
País de afiliación:
Italia