Determination of 4-methyl-cis-hexahydrophthalic anhydride in human blood by gas chromatography with electron-capture detection.
Analyst
; 116(12): 1333-6, 1991 Dec.
Article
en En
| MEDLINE
| ID: mdl-1816741
ABSTRACT
A gas-chromatographic technique using 63Ni electron-capture detection was applied to the determination of 4-methyl-cis-hexahydrophthalic anhydride in the blood of workers occupationally exposed to this airborne agent. The detection limit was 0.24 nmol ml-1. For occupational exposure to between 0.14 and 0.31 mg m-3 of the anhydride, the anhydride concentration in the workers' blood samples ranged from 3.4 to 10.7 nmol ml-1. The results are consistent with earlier findings in animal exposure experiments and support the view that the hydrolysis of the anhydride in a biological medium is not spontaneous, but might be an enzyme-catalysed reaction. The resulting dicarboxylic acid is excreted by the kidneys without further conjugation reactions.
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Colección:
01-internacional
Asunto principal:
Anhídridos Ftálicos
/
Contaminantes Ocupacionales del Aire
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Analyst
Año:
1991
Tipo del documento:
Article
País de afiliación:
Finlandia