Netrin-1 is a novel myelin-associated inhibitor to axon growth.
J Neurosci
; 28(5): 1099-108, 2008 Jan 30.
Article
en En
| MEDLINE
| ID: mdl-18234888
ABSTRACT
We investigated the influence of the bifunctional guidance molecule netrin-1 on axonal growth in the injured adult spinal cord. In the adult, netrin-1 is expressed on mature oligodendrocytes, cells of the central canal, and the meninges. Netrin-1 protein in white matter is selectively enriched adjacent to paranodal loops of myelin in nodes of Ranvier. The repulsion-mediating netrin-1 uncoordinated-5 (UNC5) receptors are expressed by neurons of the corticospinal and rubrospinal projections, and by intrinsic neurons of the spinal cord, both before and after spinal cord injury. Neutralization of netrin-1 in myelin prepared from adult rat spinal cord using UNC5 receptor bodies increases neurite outgrowth from UNC5-expressing spinal motor neurons in vitro. Furthermore, axon regeneration is inhibited in a netrin-1-enriched zone, devoid of other myelin-associated inhibitors, within spinal cord lesion sites in vivo. We conclude that netrin-1 is a novel oligodendrocyte-associated inhibitor that can contribute to axonal growth failure after adult spinal cord injury.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Axones
/
Proteínas Supresoras de Tumor
/
Proliferación Celular
/
Inhibidores de Crecimiento
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Vaina de Mielina
/
Factores de Crecimiento Nervioso
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Neurosci
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos