A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
Nature
; 452(7187): 638-642, 2008 Apr 03.
Article
en En
| MEDLINE
| ID: mdl-18385739
ABSTRACT
Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year. Evidence for genetic influence on smoking behaviour and nicotine dependence (ND) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health. Smoking is the major risk factor for lung cancer (LC) and is one of the main risk factors for peripheral arterial disease (PAD). Here we identify a common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking-related diseases in populations of European descent. The variant has an effect on the number of cigarettes smoked per day in our sample of smokers. The same variant was associated with ND in a previous genome-wide association study that used low-quantity smokers as controls, and with a similar approach we observe a highly significant association with ND. A comparison of cases of LC and PAD with population controls each showed that the variant confers risk of LC and PAD. The findings provide a case study of a gene-environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Tabaquismo
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Cromosomas Humanos Par 15
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Receptores Nicotínicos
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Enfermedades Vasculares Periféricas
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Neoplasias Pulmonares
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
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Humans
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Male
País/Región como asunto:
Europa
/
Oceania
Idioma:
En
Revista:
Nature
Año:
2008
Tipo del documento:
Article