The hydrophobicity in a chemically modified side-chain of cysteine residues of thanatin is related to antimicrobial activity against Micrococcus luteus.
Biosci Biotechnol Biochem
; 73(7): 1683-4, 2009 Jul.
Article
en En
| MEDLINE
| ID: mdl-19584529
ABSTRACT
The chemically modified thanatins with the methyl group (CH(3)), ethyl group (C(2)H(5)), and normal-octyl group (C(8)H(17)) at the side-chain of cysteine residues were synthesized. The octyl group modified form exhibited 8-fold higher antimicrobial activity against Micrococcus luteus than wild type thanatin. It was found that there was an equilateral correlation between antimicrobial activity and side-chain hydrophobicity at the cysteine residues in thanatin.
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Colección:
01-internacional
Asunto principal:
Péptidos Cíclicos
/
Micrococcus luteus
/
Cisteína
/
Interacciones Hidrofóbicas e Hidrofílicas
/
Antiinfecciosos
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Asunto de la revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Japón