Unmasking the tonic-aversive state in neuropathic pain.
Nat Neurosci
; 12(11): 1364-6, 2009 Nov.
Article
en En
| MEDLINE
| ID: mdl-19783992
ABSTRACT
Tonic pain has been difficult to demonstrate in animals. Because relief of pain is rewarding, analgesic agents that are not rewarding in the absence of pain should become rewarding only when there is ongoing pain. We used conditioned place preference to concomitantly determine the presence of tonic pain in rats and the efficacy of agents that relieve it. This provides a new approach for investigating tonic pain in animals and for evaluating the analgesic effects of drugs.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Recompensa
/
Umbral del Dolor
/
Neuralgia
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Nat Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos