Perimyocarditis following streptococcal group A infection: from clinical cases to bioinformatics analysis.
Eur J Intern Med
; 21(4): 354-6, 2010 Aug.
Article
en En
| MEDLINE
| ID: mdl-20603051
ABSTRACT
BACKGROUND:
Streptococcal infection is known to be associated with non-suppurative complications, including rheumatic fever. A less well recognized complication is perimyocarditis.METHODS:
We report 4 cases of myocarditis in young males associated with acute streptoccal infection. Following this clinical observation we employed bioinformatic techniques to identify common epitopes between Streptococcus group A and human muscle proteins. We used Blast to search all the proteome (1697 proteins) of the Streptococcus pyogenes M1 GAS against the human proteome of 34,180 proteins.RESULTS:
4 patients with streptococcal A related myocarditis were treated and made a complete recovery. One cardiac protein, ATP2A2 (NP_733765.1)), a cardiac Ca2+ ATPase, shared an epitope with Streptococcus group A and a high probability of being presented on a MHC Class II molecule.CONCLUSION:
Streptococcal myocarditis may be a commoner entity than previously appreciated. Bioinformatic techniques have identified a suspected common epitope between the streptococcal proteins and a cardiac Ca2+ ATPase.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Infecciones Estreptocócicas
/
Streptococcus pyogenes
/
Proteómica
/
Miocarditis
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Adult
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Humans
/
Male
Idioma:
En
Revista:
Eur J Intern Med
Asunto de la revista:
MEDICINA INTERNA
Año:
2010
Tipo del documento:
Article