Intra-individual variability in serum hepcidin precludes its use as a marker of iron status in hemodialysis patients.
Kidney Int
; 78(8): 769-73, 2010 Oct.
Article
en En
| MEDLINE
| ID: mdl-20668427
ABSTRACT
An accurate assessment of iron status in dialysis patients is important because both anemia and overtreatment with erythropoiesis-stimulating agents are associated with poor clinical outcomes. We have previously shown that both analytical and intra-individual (biological) variability in serum ferritin limits its utility as a proxy for iron stores in patients in this setting. As hepcidin is a direct regulator of iron status, its measurement might be useful for monitoring patients with iron dysregulation. We assessed short-term intra-individual variation of serum hepcidin in 28 patients with stable chronic kidney disease on hemodialysis. The intra-individual variability for serum hepcidin ranged from 9-79% during an initial 2-week to 12-85% over a 6-week period. The concentration of serum hepcidin was significantly correlated with serum C-reactive protein levels over the 6-week study period. Hence, significant intra-individual variability of hepcidin is likely dependent on short-term fluctuations in the inflammatory state. Thus, our results suggest that short-term measurement of serum hepcidin should not be used to guide clinical decisions regarding management of iron status in chronic hemodialysis patients.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Diálisis Renal
/
Péptidos Catiónicos Antimicrobianos
/
Insuficiencia Renal Crónica
/
Hierro
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Kidney Int
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos