Comparison of volumetric methods for tumor measurements on two and three dimensional MRI in adult glioblastoma.
Neuroradiology
; 53(8): 565-9, 2011 Aug.
Article
en En
| MEDLINE
| ID: mdl-21057780
ABSTRACT
INTRODUCTION:
Change in tumor size is a frequent endpoint in cancer clinical trials, but whether change in size should be measured using volume on two-dimensional (2D) or three-dimensional (3D) images is not certain. We compared volumetric measurements on post-contrast 2D and high-resolution 3D T1-weighted MR images (T1WI) in evaluating tumor response in glioblastoma multiforme (GBM).METHODS:
Tumor volume measurements were performed on 86 MRI studies from 37 adult patients with GBM on post-contrast 5 mm 2D T1WI and isotropic high-resolution T1WI. The means of the two volumes were compared and their association was analyzed.RESULTS:
There is no significant difference between volumes measured on 2D and 3D in 86 scans (Z = 0.63, p = 0.53), and a high correlation was revealed between them (r = 0.95, 95% CI 0.93-0.97, p < 0.001). When the percentage changes were categorized into traditional tumor response criteria (complete response/partial response/stable disease/progressive disease), the kappa coefficient between the volume on 2D and volume on 3D was 0.80 (95% CI 0.57-1.03, p < 0.05) with an overall agreement of 84%.CONCLUSIONS:
Volume on post-contrast 2D T1WI appears comparable to volume on 3D T1WI and should be a practical alternative to volume on 3D in evaluating tumor response.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Algoritmos
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Neoplasias Encefálicas
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Imagen por Resonancia Magnética
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Interpretación de Imagen Asistida por Computador
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Glioblastoma
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Imagenología Tridimensional
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neuroradiology
Año:
2011
Tipo del documento:
Article
País de afiliación:
China