Evaluation of the cytokines IL-10 and IL-13 as mediators in the progression of Symmers fibrosis in patients with hepatosplenic schistosomiasis mansoni.
Rev Col Bras Cir
; 37(5): 333-7, 2010 Oct.
Article
en En, Pt
| MEDLINE
| ID: mdl-21180998
ABSTRACT
OBJECTIVE:
To investigate the serum levels of IL-10 and IL-13 in patients with hepatosplenic schistosomiasis mansoni (HSM), evaluating the role of these cytokines in the development of hepatic fibrosis.METHODS:
The study was prospective and analytical, developed at the Department of Surgery, Federal University of Pernambuco, Keizo Asami Laboratory of Immunology. We studied three groups Group I - 25 patients with hepatosplenic schistosomiasis mansoni who were not submitted to surgery; Group II - 30 individuals who underwent splenectomy and ligature of left gastric vein; Group III - 33 subjects without hepatosplenic schistosomiasis mansoni or any other disease or condition that could compromise the hepatic functional reserve. Serum concentrations of IL-10 and IL-13 were obtained through ELISA. Considering their non-parametric nature, all concentrations were analyzed by Kruskal-Wallis test, with p<0.05 used to reject the null hypothesis.RESULTS:
The mean concentrations of IL-10 in ng/mL in serum were GI 50.0 ± 59.0; GII 38.0 ± 270; GIII 38.0 ± 20.0. Concentrations of IL-13 in ng/mL in the serum of patients were respectively 41.0 ± 93.0 in GI, 16.0 ± 17.0 in GII and 18.0 ± 34.0 in GIII. There was no significant difference between the mean concentrations of IL-10 and IL-13 between the study groups (p> 0.05).CONCLUSION:
The mean serum concentrations of IL-10 and IL-13 were similar in all three groups, indicating that possibly the presence of these cytokines in serum is not associated with different degrees of Symmers fibrosis in patients with hepatosplenic schistosomiasis mansoni.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Enfermedades del Bazo
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Esquistosomiasis mansoni
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Interleucina-10
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Interleucina-13
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Cirrosis Hepática
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Parasitosis Hepáticas
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
/
Pt
Revista:
Rev Col Bras Cir
Año:
2010
Tipo del documento:
Article
País de afiliación:
Brasil