Detection of two HLA-A alleles, A*31:30 and A*26:20, in two Taiwanese volunteer bone marrow donors by sequence-based typing.

ABSTRACT

We here report detection of a novel sequence of HLA-A*3130 and a confirmatory sequence of HLA*2620 from two Taiwanese individuals. The sequence of A*3130 is identical to that of A*310102 in exons 2 and 3, except one nucleotide (n.t.) substitution c.539T > G resulting in p.Leu180Trp. The sequence of A*2620 is identical to A*260101 in exons 2 and 3, except a segment of the sequence from n.t. 78 to n.t.102. The mismatched sequence segment is identical to a sequence segment of A*020301, suggesting that the formation of A*2620 was resulted from a DNA recombination event between A*260101 and A*020301 sequences. A*2620 differs from A*260101 with c.98A > T resulting in p.Tyr33Phe.