Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1.
Proc Natl Acad Sci U S A
; 87(10): 3723-7, 1990 May.
Article
en En
| MEDLINE
| ID: mdl-2187191
ABSTRACT
The expression of the protooncogenes ETS1 and ETS2 has been studied in purified human T cells activated either by cross-linking of the T-cell receptor-CD3 complex on their cell surface or by direct stimulation with phorbol esters and ionomycin. Our results show that resting T cells express high levels of ETS1 mRNA and protein, while expression of ETS2 is undetectable. Upon T-cell activation, ETS2 mRNA and proteins are induced, while ETS1 gene expression decreases to very low levels. Late after stimulation, ETS1 mRNA is reinduced and maintained at a high level, while ETS2 gene expression decreases to undetectable levels. Therefore, it appears that in human T cells, ETS2 gene products are associated with cellular activation and proliferation, while ETS1 gene products are preferentially expressed in a quiescent state.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Proteínas Represoras
/
Factores de Transcripción
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Proto-Oncogenes
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Activación de Linfocitos
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Linfocitos T
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Transactivadores
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Regulación de la Expresión Génica
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Genes Reguladores
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Proteínas Proto-Oncogénicas
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Proteínas de Unión al ADN
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
1990
Tipo del documento:
Article