Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38.
J Antibiot (Tokyo)
; 64(12): 775-80, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-22008702
ABSTRACT
Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Streptomyces
/
Policétidos
Límite:
Humans
País/Región como asunto:
America do sul
/
Chile
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
2011
Tipo del documento:
Article
País de afiliación:
Alemania