Analysis of prognosis-related factors in patients with invasive cervical adenocarcinoma.

OBJECTIVE: To explore the prognostic related factors in patients with cervical adenocarcinoma. METHODS: Clinical and pathological data were retrospectively analyzed in 144 patients with cervical adenocarcinoma between 1995 and 2004. RESULTS: Five-year survival rates were 80.1%, 59.7%, 6.3 % and 0.0%, respectively, in patients with Stage I, II, III and IV cervical adenocarcinoma, and the overall 5-year survival rate was 59.0%. Univariate analysis indicated poor prognosis in non-exophytic tumor, tumor diameter > 4 cm, advanced clinical stage, mucinous adenocarcinoma and clear cell carcinoma, or poorly differentiated tumor. The prognosis was related to lymph node metastasis and deep myometrial invasion. Multivariate analysis indicated that besides clinical stage, myometrial invasion and lymph node metastasis, tumor shape was also an independent prognostic related factor. CONCLUSION: The prognosis is associated with tumor shape besides pre-confirmed clinical stage, myometrial invasion and lymph node metastasis. Ovarian preservation in young women remains to be further explored.