Cyclic ether-containing macrolactins, antimicrobial 24-membered isomeric macrolactones from a marine Bacillus sp.
J Nat Prod
; 74(12): 2582-7, 2011 Dec 27.
Article
en En
| MEDLINE
| ID: mdl-22133265
ABSTRACT
Bioassay-guided isolation of bioactive metabolites from the ethyl acetate extract of a marine Bacillus sp. fermentation broth has led to the discovery of three new 24-membered macrolactones, macrolactins 1-3, which contain an oxetane, an epoxide, and a tetrahydropyran ring, respectively. The configurations of 1-3 were assigned by a combination of coupling constants, ROESY data analysis, and application of the modified Mosher's method. Compounds 1-3 showed in vitro antimicrobial activity.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Bacillus
/
Éteres Cíclicos
/
Antiinfecciosos
Idioma:
En
Revista:
J Nat Prod
Año:
2011
Tipo del documento:
Article