Prenatal hazardous substance use and adverse birth outcomes.
J Matern Fetal Neonatal Med
; 25(8): 1222-7, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22489543
ABSTRACT
OBJECTIVE:
Assess the relative effects of a variety of illicit and licit drugs on risk for adverse birth outcomes.METHODS:
We used data from two large prospective investigations, and a novel analytic method, recursive partitioning class analysis to identify risk factors associated with preterm birth and delivering a small for gestational age infant.RESULTS:
Compared to cocaine and opiate non-users, cocaine users were 3.53 times as likely (95% CI 1.65-7.56; p = 0.001) and opiate users 2.86 times as likely (95% CI 1.11-7.36; p = 0.03) to deliver preterm. The odds of delivering a small for gestational age infant for women who smoked more than two cigarettes daily was 3.74, (95% CI 2.47-5.65; p<0.0001) compared to women who smoked two or less cigarettes daily and had one previous child. Similarly, less educated, nulliparous women who smoked two or fewer cigarettes daily were 4.12 times as likely (95% CI 2.04-8.34; p < 0.0001) to have a small for gestational age infant.CONCLUSIONS:
Among our covariates, prenatal cocaine and opiate use are the predominant risk factors for preterm birth; while tobacco use was the primary risk factor predicting small for gestational age at delivery. Multi-substance use did not substantially increase risk of adverse birth outcomes over these risk factors.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
/
Resultado del Embarazo
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Sustancias Peligrosas
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Trastornos Relacionados con Sustancias
Tipo de estudio:
Etiology_studies
/
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
J Matern Fetal Neonatal Med
Asunto de la revista:
OBSTETRICIA
/
PERINATOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos