Selective inhibition of USP7.
Chem Biol
; 19(4): 437-8, 2012 Apr 20.
Article
en En
| MEDLINE
| ID: mdl-22520747
ABSTRACT
The deubiquitinating enzyme USP7 is an emerging oncology and antiviral target. Reverdy et al., in this issue of Chemistry & Biology, disclose the first small-molecule inhibitor selective for USP7, which recapitulates its knockdown in cancer cells and hence demonstrates the therapeutic feasibility of USP7 inhibitors.
Texto completo:
1
Colección:
01-internacional
Idioma:
En
Revista:
Chem Biol
Asunto de la revista:
BIOLOGIA
/
BIOQUIMICA
/
QUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Canadá