Lxrα regulates the androgen response in prostate epithelium.
Endocrinology
; 153(7): 3211-23, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22547570
ABSTRACT
Benign prostatic hyperplasia is a nonmalignant enlargement of the prostate that commonly occurs in older men. We show that liver X receptor (Lxr)-α knockout mice (lxrα(-/-)) develop ventral prostate hypertrophy, correlating with an overaccumulation of secreted proteins in prostatic ducts and an alteration of vesicular trafficking in epithelial cells. In the fluid of the lxrα(-/-) prostates, spermine binding protein is highly accumulated and shows a 3000-fold increase of its mRNA. This overexpression is mediated by androgen hypersensitivity in lxrα(-/-) mice, restricted to the ventral prostate. Generation of chimeric recombinant prostates demonstrates that Lxrα is involved in the establishment of the epithelial-mesenchymal interactions in the mouse prostate. Altogether these results point out the crucial role of Lxrα in the homeostasis of the ventral prostate and suggest lxrα(-/-) mice may be a good model to investigate the molecular mechanisms of benign prostatic hyperplasia.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Próstata
/
Regulación de la Expresión Génica
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Células Epiteliales
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Receptores Nucleares Huérfanos
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Andrógenos
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Endocrinology
Año:
2012
Tipo del documento:
Article
País de afiliación:
Francia