Targeted gene delivery by free-tissue transfer in oncoplastic reconstruction.
Lancet Oncol
; 13(9): e392-402, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-22935239
ABSTRACT
Surgery is the most effective curative treatment for various tumour types. Despite a current preference for conservative surgery, radical excision retains a clearly defined role in modern management of locoregional disease. Extirpative defects are reconstructed routinely using free-tissue transfer from a distant donor site. Although these free flaps currently provide no direct therapeutic benefit, advances in gene-delivery techniques offer the possibility to genetically modify flaps to produce potent targeted treatments with greater anatomical control. Several promising therapeutic strategies, including virus-directed enzyme prodrug therapy, genetic radionuclide therapy, and free-flap radioprotection, have the potential to extend the role of the free flap beyond its immediate goal of restoring form and function to patients, but challenges exist. Work to translate therapeutic free-tissue transfer from preclinical study to clinical use is in progress.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Colgajos Quirúrgicos
/
Técnicas de Transferencia de Gen
/
Procedimientos de Cirugía Plástica
/
Neoplasias
Idioma:
En
Revista:
Lancet Oncol
Asunto de la revista:
NEOPLASIAS
Año:
2012
Tipo del documento:
Article
País de afiliación:
Reino Unido