Cytogenetics findings in a histiocytic sarcoma case.
Case Rep Hematol
; 2012: 428279, 2012.
Article
en En
| MEDLINE
| ID: mdl-22937328
ABSTRACT
Histiocytic sarcoma (HS) is a neoplasm derived from histiocytes. Its diagnosis was not clear until its immunohistochemistry profile was correctly established. Not much is known about its genetic properties. We report a case of a 48-year-old male patient whose bone marrow was almost completely occupied by monomorphic medium size neoplastic cellularity. Its immunohistochemical profile was CD68(+), CD4(+), CD45(+) with negativity of other dendritic cells, and other lineage markers. Cytogenetic study showed 4 related clones one with trisomy 8 and extra material on the short arms of chromosome 4; a second line with tetrasomy of chromosome 8, add(4)(p16); the third clone had the same alterations as the previous and deletion of chromosome 3 at q11; the fourth line had tetrasomy 8 and translocation t(3;5)(q25;q35). To our knowledge this is the first HS case showing chromosome 8 trisomy and tetrasomy and the other described alterations.
Texto completo:
1
Colección:
01-internacional
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Case Rep Hematol
Año:
2012
Tipo del documento:
Article
País de afiliación:
España