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Cytogenetics findings in a histiocytic sarcoma case.
Alonso-Dominguez, J M; Calbacho, M; Talavera, M; Villalon, C; Abalo, L; Garcia-Gutierrez, J V; Lozano, S; Tenorio, M; Villarrubia, J; Lopez-Jimenez, J; Ferro, M T.
Afiliación
  • Alonso-Dominguez JM; Servicio de Hematología, Hospital Ramón y Cajal, Carretera de Colmenar Km 9, 100 28049 Madrid, Spain.
Case Rep Hematol ; 2012: 428279, 2012.
Article en En | MEDLINE | ID: mdl-22937328
ABSTRACT
Histiocytic sarcoma (HS) is a neoplasm derived from histiocytes. Its diagnosis was not clear until its immunohistochemistry profile was correctly established. Not much is known about its genetic properties. We report a case of a 48-year-old male patient whose bone marrow was almost completely occupied by monomorphic medium size neoplastic cellularity. Its immunohistochemical profile was CD68(+), CD4(+), CD45(+) with negativity of other dendritic cells, and other lineage markers. Cytogenetic study showed 4 related clones one with trisomy 8 and extra material on the short arms of chromosome 4; a second line with tetrasomy of chromosome 8, add(4)(p16); the third clone had the same alterations as the previous and deletion of chromosome 3 at q11; the fourth line had tetrasomy 8 and translocation t(3;5)(q25;q35). To our knowledge this is the first HS case showing chromosome 8 trisomy and tetrasomy and the other described alterations.

Texto completo: 1 Colección: 01-internacional Tipo de estudio: Diagnostic_studies Idioma: En Revista: Case Rep Hematol Año: 2012 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Colección: 01-internacional Tipo de estudio: Diagnostic_studies Idioma: En Revista: Case Rep Hematol Año: 2012 Tipo del documento: Article País de afiliación: España