Expression of α4ß7 integrin on memory CD8(+) T cells at the presentation of acute intestinal GVHD.
Bone Marrow Transplant
; 48(4): 598-603, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23042495
ABSTRACT
Acute intestinal GVHD remains a major source of morbidity after allogeneic hematopoietic cell transplantation (HCT). α4ß7 integrin is a cell surface molecule that mediates lymphocyte trafficking to intestinal tissue. In this analysis, peripheral blood was collected at the time of presentation of symptoms of acute GVHD and before any treatment. In all, 45 samples were collected and divided into three groups on the basis of subsequent evaluation intestinal GVHD (n=15), skin GVHD (n=20) and no GVHD (n=10). Two patients developed intestinal GVHD after DLI. The no-GVHD group comprised 10 patients who presented with suspicious symptoms, but evaluation yielded other etiologies. Analysis by flow cytometry showed that intestinal GVHD patients had a significantly higher percentage of α4ß7 integrin-expressing memory CD8(+) T cells (median 7.69%; lower and upper quartiles, 1.06% and 11.64%, respectively) compared with patients with skin GVHD (1.26%; 0.57% and 2.49%) and no GVHD (0.96%; 0.44% and 1.85%), P=0.03. No differences were found in α4ß7 expression in any CD4(+) T-cell subsets or naive CD8(+) T cells. This study adds to the evidence that α4ß7 integrin is involved in lymphocyte trafficking in acute intestinal GVHD.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Regulación de la Expresión Génica
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Trasplante de Células Madre Hematopoyéticas
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Linfocitos T CD8-positivos
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Integrina alfa4
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Cadenas beta de Integrinas
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Enfermedad Injerto contra Huésped
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Memoria Inmunológica
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Enfermedades Intestinales
Tipo de estudio:
Clinical_trials
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Etiology_studies
Límite:
Female
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Humans
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Male
Idioma:
En
Revista:
Bone Marrow Transplant
Asunto de la revista:
TRANSPLANTE
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos