Serum sex steroid levels and longitudinal changes in bone density in relation to the final menstrual period.
J Clin Endocrinol Metab
; 98(4): E654-63, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23443812
ABSTRACT
CONTEXT The associations of serum sex steroid and FSH levels with change of bone mineral density (BMD) across the complete menopausal transition are incompletely understood. OBJECTIVE:
The objective of the study was to examine the associations of annual serum levels of FSH, estradiol (E2), T, and SHBG with the rates of bone loss in 3 phases pretransmenopausal [baseline to 1 year before the final menstrual period (FMP)], transmenopausal (1 year before to 2 years after the FMP), later postmenopausal (≥ 2 years after the FMP).DESIGN:
The design of the study was a repeated-measures, mixed-effects regression.SETTING:
This was a community-based observational study, with a 10-year follow-up.PARTICIPANTS:
A total of 720 participants of the Study of Women's Health Across the Nation Bone Study participated in the study. OUTCOMEMEASURES:
Annualized lumbar spine (LS) and femoral neck (FN) BMD decline was measured.RESULTS:
The mean annual change in BMD was slowest in pretransmenopause (0.27%/year in FN) and fastest in transmenopause (2.16%/year in LS). In the pretransmenopausal phase, for every doubling of FSH level, LS BMD change was faster by -0.32%/year (P < .0001). In the transmenopausal phase, for every doubling of FSH level, LS BMD change was -0.35%/year faster (P < .0001); for every doubling of SHBG level, LS BMD change was -0.36%/year faster (P < .0001). In the later postmenopausal phase, for each doubling of the E2 level, the LS BMD change was slower by +0.26%/year (P = .049); for each SHBG doubling, the LS BMD change was 0.21%/year slower (P = .048). The FN associations were weaker and inconsistent.CONCLUSIONS:
Higher E2 levels and lower FSH levels were associated with lower rates of LS bone loss in some but not all menopausal transition phases.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Hormonas Esteroides Gonadales
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Menopausia
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Densidad Ósea
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Menstruación
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
J Clin Endocrinol Metab
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos