Expression and prognostic significance of hsa-miR-142-3p in acute leukemias.
Neoplasma
; 60(4): 432-8, 2013.
Article
en En
| MEDLINE
| ID: mdl-23581416
ABSTRACT
OBJECTIVES:
The microRNA 142 (miR-142) is expressed at high levels in mature hematopoietic cells and has a crucial role during T-lymphocyte development. Its role in leukemogenesis is unclear. PATIENTS ANDMETHODS:
Expression of miR-142 was analyzed in acute myeloid and lymphoblastic leukemia cells (de novo, cell lines). Data were compared to expression in CD34+ hematopoietic cells. Based on the miR-142 expression, clinical data such as overall survival was analyzed.RESULTS:
MiR-142 expression in all leukemia cell lines and 86 % of the de novo samples was higher than in CD34+ cells. This difference could be detected in both, myeloid and lymphoid neoplastic cells. In AML patients with intermediate cytogenetic risk a high miR-142 expression was associated with a better overall survival.CONCLUSIONS:
MiR-142 expression in acute lymphoblastic as well as myeloid leukemia cells is higher than in CD34+ cells. Additionally, miR-142 expression might have prognostic relevance in AML-patients with otherwise an intermediate cytogenetic risk.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Leucemia Mieloide Aguda
/
MicroARNs
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Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Aged80
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neoplasma
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania