Induced pluripotent stem cells and hepatic differentiation.
J Chin Med Assoc
; 76(11): 599-605, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-23933345
ABSTRACT
Induced pluripotent stem cells (iPSCs) are generated by reprogramming somatic cells to a pluripotent state by the introduction of specific factors. They can be generated from cells of different origins, such as fibroblasts, keratinocytes, hepatocytes, and blood. iPSCs are similar to embryonic stem cells (ESCs) in several aspects, such as morphology, expression of pluripotency markers, and the ability to develop teratoma that contains tissue from three germ layers. In addition, iPSCs can undergo tridermal differentiation, including hepatic specific lineages. Considering that iPSCs could be a source of hepatocyte regeneration, iPSC-based therapy has been widely implicated in the treatment of liver disease and hepatic regeneration. In the present review, we discuss the therapeutic potential of iPSCs in hepatic repair and focus on the clinical applications of iPSCs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Células Madre Pluripotentes Inducidas
/
Hígado
Límite:
Humans
Idioma:
En
Revista:
J Chin Med Assoc
Asunto de la revista:
MEDICINA
Año:
2013
Tipo del documento:
Article