[Iron-deficiency anemia].
Nihon Rinsho
; 71(8): 1462-6, 2013 Aug.
Article
en Ja
| MEDLINE
| ID: mdl-23967680
ABSTRACT
Numerous studies have suggested a link between iron-deficiency anemia(IDA) and Helicobacter pylori infection. Previously, we found that strains isolated from IDA patients showed higher levels of Fe ion uptake and Fe-iron-dependent rapid proliferation than those of strains derived from patients without IDA. Recently we examined the nucleotide sequences of nap A, fur, and feo B of H. pylori strains from 24 IDA patients and those from 25 non-IDA patients. Frequency of neutrophil-activating protein A(Nap A), which encoded by nap A, with threonine at amino acid residue No. 70 (Thr70-type Nap A) was significantly higher in IDA strains than non-IDA strains. Strains with Thr70-type Nap A showed significantly higher levels of Fe3+ and Fe2+ uptake than strains with other type, Ser70-type Nap A, which is found in standard strains.
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Colección:
01-internacional
Asunto principal:
Helicobacter pylori
/
Infecciones por Helicobacter
/
Anemia Ferropénica
/
Hierro
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
Ja
Revista:
Nihon Rinsho
Año:
2013
Tipo del documento:
Article