miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor.
J Clin Pathol
; 67(3): 198-203, 2014 Mar.
Article
en En
| MEDLINE
| ID: mdl-24098024
ABSTRACT
AIMS:
miR-181a expression is frequently altered in different types of cancer. Members of the Wnt/ß-catenin signalling pathway, which is commonly altered in colorectal cancer (CRC), have been reported as molecular interaction partners of miR-181. However, the role of miR-181a expression in CRC and its ability to predict survival and response to agents targeting the epidermal growth factor receptor (EGFR) have not been explored yet.METHODS:
In this study, we analysed 80 patients with wild type KRAS CRC undergoing treatment with the EGFR-targeting monoclonal antibodies cetuximab and panitumumab for metastatic CRC. The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue. The microRNA expression levels were correlated with clinicopathological characteristics. Cancer-specific survival was calculated by univariate and multivariate analyses, and progression-free survival (PFS) during treatment with EGFR-targeting agents was also evaluated.RESULTS:
A low miR-181a expression level was associated with poor differentiation of CRC (p=0.04). A Kaplan-Meier curve showed a decreased survival time for patients with low miR-181a expression (p=0.019). Low miR-181a expression was furthermore associated with poor PFS (p=0.015).CONCLUSIONS:
In conclusion, our data suggest that the miR-181a expression level is associated with poor survival in patients with CRC. Furthermore, miR-181a expression might predict PFS in EGFR-targeted therapy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Neoplasias Colorrectales
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MicroARNs
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Inhibidores de Proteínas Quinasas
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Anticuerpos Monoclonales Humanizados
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Receptores ErbB
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Anticuerpos Monoclonales
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Antineoplásicos
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
Idioma:
En
Revista:
J Clin Pathol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Austria