Successful treatment of an infant with CDA type II by intrauterine transfusions and postnatal stem cell transplantation.
Pediatr Blood Cancer
; 61(4): 743-5, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24123799
ABSTRACT
Congenital dyserythropoietic anemias are rare hematological disorders leading to ineffective erythropoiesis with chronic anemia, complicated by iron overload. Here we present a remarkable clinical course of an infant with CDA type II who first presented as a severe fetal hydrops, requiring serial intrauterine red cell transfusions. While postnatal transfusion dependency persisted, the patient was successfully transplanted with a myeloablative conditioning regimen and peripheral blood stem cells of a matched donor. We believe that allogeneic HSCT is a reasonable therapeutic approach for patients with very severe CDA, even if only a matched unrelated donor is available.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Transfusión de Sangre Intrauterina
/
Trasplante de Células Madre
/
Anemia Diseritropoyética Congénita
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Infant
/
Pregnancy
Idioma:
En
Revista:
Pediatr Blood Cancer
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Alemania