A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.
PLoS Comput Biol
; 10(2): e1003493, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24586139
ABSTRACT
Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Zoonosis
/
Infecciones por Retroviridae
/
Citosina Desaminasa
/
Virus Espumoso de los Simios
/
Mutación
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
PLoS Comput Biol
Asunto de la revista:
BIOLOGIA
/
INFORMATICA MEDICA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos